Severity of Depression, Anxious Distress and the Risk of Cardiovascular Disease in a Swedish Population-Based CohortReport as inadecuate




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Background

Depression is known to be associated with cardiovascular diseases CVD. This population-based cohort study aimed to determine the association between depression of varying severity and risk for CVD and to study the effect of concomitant anxious distress on this association.

Methods

We utilized data from a longitudinal cohort study of mental health, work and relations among adults 20–64 years, with a total of 10,443 individuals. Depression and anxious distress were assessed using psychiatric rating scales and defined according to DSM-5. Outcomes were register-based and self-reported cardiovascular diseases.

Findings

Overall increased odds ratios of 1.5 to 2.6 were seen for the different severity levels of depression, with the highest adjusted OR for moderate depression OR 2.1 95% CI 1.3, 3.5. Similar odds ratios were seen for sub-groups of CVD: ischemic-hypertensive heart disease and stroke, 2.4 95% CI 1.4, 3.9 and OR 2.1 95%CI 1.2, 3.8 respectively. Depression with anxious distress as a specifier of severity showed OR of 2.1 95% CI 1.5, 2.9 for CVD.

Conclusion

This study found that severity level of depression seems to be of significance for increased risk of CVD among depressed persons, although not in a dose-response manner which might be obscured due to treatment of depression. Further, we found a higher risk of CVD among depressed individuals with symptoms of anxious distress.



Author: Aysha Almas , Yvonne Forsell, Romaina Iqbal, Imre Janszky, Jette Moller

Source: http://plos.srce.hr/



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