Diagnostic Value of the Combination of Golgi Protein 73 and Alpha-Fetoprotein in Hepatocellular Carcinoma: A Meta-AnalysisReport as inadecuate




Diagnostic Value of the Combination of Golgi Protein 73 and Alpha-Fetoprotein in Hepatocellular Carcinoma: A Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Conflicting results have been widely reported on the use of Golgi protein 73 GP73 as a serum biomarker for diagnosing hepatocellular carcinoma HCC. This study evaluated the accuracy of GP73, alpha-fetoprotein AFP, and GP73 + AFP for diagnosing HCC. The meta-analysis was performed on 11 studies that were selected by means of a comprehensive systematic literature review. Summary diagnostic accuracy, meta-regression analysis for heterogeneity and publication bias, and other statistical analyses were performed using Meta-Disc version 1.4 and Stata version 12.0. Pooled sensitivity, specificity, and diagnostic odds ratio were 0.77 95% CI: 0.75–0.79, 0.91 95% CI: 0.90–0.92, and 12.49 95% CI: 4.91–31.79 for GP73; 0.62 95% CI: 0.60–0.64, 0.84 95% CI: 0.83–0.85, and 11.61 95% CI: 8.02–16.81 for AFP; and 0.87 95% CI: 0.85–0.89, 0.85 95% CI: 0.84–0.86, and 30.63 95% CI: 18.10–51.84 for GP73 + AFP. The area under the curve values were 0.86, 0.84, and 0.91 for GP73, AFP, and GP73 + AFP, respectively. These results indicate that for HCC diagnosis, the accuracy of GP73 was higher than that of AFP, and that GP73 + AFP exhibited significantly higher diagnostic accuracy than did GP73 or AFP alone.



Author: Meiyu Dai , Xiaoli Chen , Xuexiang Liu, Zheng Peng, Jie Meng, Shengming Dai

Source: http://plos.srce.hr/



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