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Journal of OncologyVolume 2010 2010, Article ID 767384, 6 pages

Review ArticleDivision of Cardiology, and Molecular and Vascular Biology, Department of Medicine, Research North RM 270D, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA

Received 20 October 2009; Revised 6 February 2010; Accepted 2 March 2010

Academic Editor: Debabrata Mukhopadhyay

Copyright © 2010 Peter Oettgen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Angiogenesis is a critical component of tumor growth. A number of growth factors, including VEGF, FGF, and HGF, have been implicated as angiogenic growth factors that promote tumor angiogenesis in different types of cancer. Ets-1 is the prototypic member of the Ets transcription factor family. Ets-1 is known to be a downstream mediator of angiogenic growth factors. Expression of Ets-1 in a variety of different tumors is associated with increased angiogenesis. A role for other selected members of the Ets transcription factor family has also been shown to be important for the development of tumor angiogenesis. Because Ets factors also express a number of other important genes involved in cell growth, they contribute not only to tumor growth, but to disease progression. Targeting Ets factors in mouse tumor models through the use of dominant-negative Ets proteins or membrane permeable peptides directed at competitively inhibiting the DNA binding domain has now demonstrated the therapeutic potential of inhibiting selected Ets transcription factors to limit tumor growth and disease progression.

Author: Peter Oettgen



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