GlycA, a Pro-Inflammatory Glycoprotein Biomarker, and Incident Cardiovascular Disease: Relationship with C-Reactive Protein and Renal FunctionReport as inadecuate




GlycA, a Pro-Inflammatory Glycoprotein Biomarker, and Incident Cardiovascular Disease: Relationship with C-Reactive Protein and Renal Function - Download this document for free, or read online. Document in PDF available to download.

Objective

GlycA is a novel nuclear magnetic resonance spectroscopy-measured biomarker of systemic inflammation. We determined whether GlycA is associated with incident cardiovascular disease CVD in men and women, examined whether this association with CVD is modified by renal function, and compared this association with high sensitivity C-reactive protein hsCRP.

Research design and methods

A prospective cohort study was performed among 4,759 subjects PREVEND study without a history of CVD and cancer. Incident CVD was defined as the combined endpoint of cardiovascular morbidity and mortality. Cox regression analyses were used to examine associations of baseline GlycA and hsCRP with CVD.

Results

298 first CVD events occurred during a median follow-up of 8.5 years. After adjustment for clinical and lipid measures the hazard ratio HR for CVD risk in the highest GlycA quartile was 1.58 95% CI, 1.05–2.37, P for trend = 0.004. This association was similar after further adjustment for renal function estimated glomerular filtration rate and urinary albumin excretion. After additional adjustment for hsCRP, GlycA was still associated with incident CVD HR: 1.16 per SD change 95% CI, 1.01–1.33, P = 0.04. Similar results were obtained for hsCRP HR per SD change after adjustment for GlycA: 1.17 95% CI 1.17 95% CI, 1.01–3.60, P = 0.04. CVD risk was highest in subjects with simultaneously higher GlycA and hsCRP fully adjusted HR: 1.79 95% CI, 1.31–2.46, P<0.001.

Conclusion

GlycA is associated with CVD risk in men and women, independent of renal function. The association of GlycA with incident CVD is as strong as that of hsCRP.



Author: Eke G. Gruppen , Ineke J. Riphagen, Margery A. Connelly, James D. Otvos, Stephan J. L. Bakker, Robin P. F. Dullaart

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents