The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery StenosisReport as inadecuate




The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis - Download this document for free, or read online. Document in PDF available to download.

Oxidative Medicine and Cellular Longevity - Volume 2016 2016, Article ID 1789596, 8 pages -

Research Article

Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland

Department of Neurology, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland

Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Szamarzewskiego Str. 82-84, 60-569 Poznan, Poland

Department of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland

Department of General and Interventional Radiology, Poznan University of Medical Sciences, Dluga Str. 1-2, 61-848 Poznan, Poland

Received 19 August 2016; Accepted 24 October 2016

Academic Editor: Janusz Gebicki

Copyright © 2016 Slawomir Michalak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The treatment of carotid artery stenosis is associated with the risk of complications, which may include stroke after carotid artery stenting CAS and myocardial infarction after carotid endarterectomy CEA. The imbalance between prooxidative mechanisms and antioxidant capacity creates a milieu of factors, which may increase the risk of complications after endovascular procedures. We have examined 43 consecutive patients with carotid artery stenosis. Sera were analyzed for the activity of paraoxonase PON and arylesterase ARE, sulfhydryl groups SG, malondialdehyde MDA, and conjugated dienes CD concentrations by means of spectrophotometric methods before and next day after CAS. We have found lowered PON , increase in ARE activity , and decrease in sulfhydryl groups concentration . No effect on absolute MDA and CD concentrations was observed. The degree of carotid artery stenosis correlated negatively with PON-ARE ratio after CAS = −0.507, . To conclude, CAS influences both enzymatic differently, PON and ARE activity and nonenzymatic antioxidant defense. Females are more susceptible to lipid peroxidation after CAS. PON-ARE ratio after CAS correlated with the degree of carotid artery stenosis. The changes deltas in ARE activity, SG, and MDA concentrations correlated with the severity of neurological deficit and disability.





Author: Slawomir Michalak, Wojciech Ambrosius, Ewa Wysocka, Mieczyslaw Dziarmaga, Robert Juszkat, Andrzej Wykretowicz, and Wojciech

Source: https://www.hindawi.com/



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