Rabdosia japonica var. glaucocalyx Flavonoids Fraction Attenuates Lipopolysaccharide-Induced Acute Lung Injury in MiceReport as inadecuate




Rabdosia japonica var. glaucocalyx Flavonoids Fraction Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice - Download this document for free, or read online. Document in PDF available to download.

Evidence-Based Complementary and Alternative Medicine - Volume 2014 2014, Article ID 894515, 12 pages -

Research Article

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China

School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong

Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China

Received 15 April 2014; Accepted 18 May 2014; Published 9 June 2014

Academic Editor: Shi-Biao Wu

Copyright © 2014 Chun-jun Chu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rabdosia japonica var. glaucocalyx Maxim. Hara, belonging to the Labiatae family, is widely used as an anti-inflammatory and antitumor drug for the treatment of different inflammations and cancers. Aim of the Study. To investigate therapeutic effects and possible mechanism of the flavonoids fraction of Rabdosia japonica var. glaucocalyx Maxim. Hara RJFs in acute lung injury ALI mice induced by lipopolysaccharide LPS. Materials and Methods. Mice were orally administrated with RJFs 6.4, 12.8, and 25.6 mg-kg per day for 7 days, consecutively, before LPS challenge. Lung specimens and the bronchoalveolar lavage fluid BALF were isolated for histopathological examinations and biochemical analysis. The level of complement 3 C3 in serum was quantified by a sandwich ELISA kit. Results. RJFs significantly attenuated LPS-induced ALI via reducing productions of the level of inflammatory mediators TNF-α, IL-6, and IL-1β, and significantly reduced complement deposition with decreasing the level of C3 in serum, which was exhibited together with the lowered myeloperoxidase MPO activity and nitric oxide NO and protein concentration in BALF. Conclusions. RJFs significantly attenuate LPS-induced ALI via reducing productions of proinflammatory mediators, decreasing the level of complement, and reducing radicals.





Author: Chun-jun Chu, Nai-yu Xu, Xian-lun Li, Long Xia, Jian Zhang, Zhi-tao Liang, Zhong-zhen Zhao, and Dao-feng Chen

Source: https://www.hindawi.com/



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