Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic RatsReport as inadecuate




Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats - Download this document for free, or read online. Document in PDF available to download.

Echinocystic acid EA is a natural triterpone enriched in various herbs and has been used for medicinal purposes in China. In the present study, we systematically examined the effects of EA on ovariectomy-induced osteoporosis in rats for the first time. Three-month-old female ovariectomy OVX Sprague–Dawley rats were used to evaluate the osteoprotective effect of EA. Results showed that administration of EA 5 or 15 mg-kg-day for 12 weeks prevented lower levels of maximum stress and Young’s modulus of femur induced by OVX. EA also recovered bone metabolic biomarkers levels in OVX rats, including osteocalcin, alkaline phosphatese, deoxypyridinoline, and urinary calcium and phosphorus. EA 5 and 15 mg-kg-day could prevent the alteration of total bone mineral density in the femur caused by OVX. However, only high dose 15 mg-kg-day of EA significantly improved trabecular architecture, as evidenced by higher levels of bone volume-tissue volume, trabecula number, and trabecula thickness, and lower levels of trabecula separation and structure model index compared with OVX rats. In addition, EA treatment decresed the serum levels of IL-1β and TNF-α in OVX rats. In conclusion, EA could prevent reduction of bone mass and strength and improve the cancellous bone structure and biochemical properties in OVX rats. Hence, EA may serve as a new candidate or a leading compound for anti-osteoporosis.



Author: Ya-ting Deng , Wen-bo Kang , Jian-ning Zhao , Gang Liu , Ming-gao Zhao

Source: http://plos.srce.hr/



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