NEUROTRANSMITTER MEASURES IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMERS DISEASE: A REVIEWReport as inadecuate




NEUROTRANSMITTER MEASURES IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMERS DISEASE: A REVIEW - Download this document for free, or read online. Document in PDF available to download.

Psychiatria Danubina, Vol.27 No.1 March 2015. -

Background: Alzheimer-s disease AD is a severe neurodegenerative disorder characterized by progressive cognitive and

functional decline, as well as by a variety of neuropsychiatric and psychological symptoms and behavioral dysfunctions. Various

studies proposed the role of different neurotransmitter systems not only in AD-related cognitive, but also psychotic symptoms and

behavioral and emotional deficits. Due to the close proximity, pathological neurochemical changes in brain occurring in AD are

likely to be reflected in the cerebrospinal fluid CSF. The purpose of this review is to provide a summary of the CSF

neurotransmitter correlates of AD in order to get further insights into the potential role of altered neurotransmitters in the

pathophysiology of AD and to offer novel AD biomarkers.

Methods: PubMed and MEDLINE data bases were searched for English-language articles by using -Alzheimer-s disease-,

-CSF- and -neurotransmitter- as primary terms. No time or article type constraints were applied. Moreover, the lists of references

were searched manually for additional articles.

Results: Changes in various correlates of cholinergic, monoaminergic and amino acid neurotransmitter systems, as well as

neuropeptides, have been observed in CSF of AD patients. However, as the results of these studies have been controversial, the

importance of CSF neurotransmitter parameters as potential biomarkers in AD remains quite unclear. The observed discrepancies

could be bypassed by implementation of new sensitive methods, such as novel proteomics approaches that include protein separation

techniques, mass spectroscopy and targeted multiplex panels of specific analytes.

Conclusion: Although no individual CSF neurotransmitter correlate was demonstrated as suitable biomarker of AD, a combined

profile of several CSF neurochemical parameters might show enhanced sensitivity and specificity and thus contribute to earlier and

more accurate diagnosis of AD, crucial for application of effective treatments.

Alzheimer-s disease - biomarkers - CSF - neurotransmitters – review



Author: Dubravka Svob Strac - orcid.org-0000-0001-6200-2405 ; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia

Source: http://hrcak.srce.hr/



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