Selected Health Factors Pulse Pressure, Type 2 Diabetes and Genetic Polymorphisms ApoE, IDE rs6583817 Play Independent and Interactive Roles in Patterns of Cognitive Performance and Change in Older AdultsReport as inadecuate




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Aging, Pulse Pressure, IDE, Declarative Memory, gene x health interaction analyses, ApoE, Executive Function, Type 2 Diabetes

McFall, Georgia, Peggy

Supervisor and department: Dixon, Roger Psychology

Examining committee member and department: Sheree Kwong See Psychology Nikolai Malykhin Biomedical Engineering Tammy Hopper Rehabilitation Medicine Kaarin Anstey Australian National University Sandra Wiebe Psychology

Department: Department of Psychology

Specialization:

Date accepted: 2014-03-26T11:54:45Z

Graduation date: 2014-06

Degree: Doctor of Philosophy

Degree level: Doctoral

Abstract: Objective: This gene x environment health dissertation focused on concurrent and longitudinal change in performance on executive function EF and declarative memory DM latent variables by normal aging adults. Specifically, we report three studies that tested the independent and interactive effects of a Insulin degrading enzyme IDE and type 2 diabetes T2D across 2 waves of EF data, b IDE and pulse pressure PP across 3 waves of EF data, and c Apolipoprotein E ApoE and PP across 3 waves of DM data for older adults from the Victoria Longitudinal Study. Method: We assembled a sample of non-demented older adults n = 683, M age = 71, Age range = 53-95 from which we drew a slightly different group for each study. We used latent growth modeling to test a series of similar research goals within each study. Results: First, for Study 1, we confirmed a single factor EF model and reported independent but unrelated non-interactive effects of T2D and IDE on EF performance. Second, for Study 2, we confirmed a single factor EF model and reported independent and interactive effects of PP and IDE on EF performance. Regarding the interactive effect of PP x IDE, higher PP differentially affected EF performance in older adults with the IDE G allele. Third, for Study 3, we confirmed a DM model made up of a single factor episodic memory EM model and a single factor semantic memory SM model that we ran in parallel. We reported independent effects of PP on the baseline level of EM but not SM but no independent effects of ApoE on EM or SM performance patterns. Regarding the interactive effect of PP x ApoE, EM performance and change was differentially affected by higher PP for adults with an ApoE ε3 or ε4 allele as compared with carriers of the potentially protective ε2 allele. Discussion: Genetic x health interaction analyses as performed on both concurrent and longitudinal data can reveal differential and magnifying effects of biological risk factors on cognitive aging. In the present case both IDE x PP and ApoE x PP affect concurrent and changing cognitive health in aging.

Language: English

DOI: doi:10.7939-R30Q2V

Rights: Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.





Author: McFall, Georgia, Peggy

Source: https://era.library.ualberta.ca/


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University of Alberta Selected Health Factors (Pulse Pressure, Type 2 Diabetes) and Genetic Polymorphisms (ApoE, IDE rs6583817) Play Independent and Interactive Roles in Patterns of Cognitive Performance and Change in Older Adults by Georgia Peggy McFall A thesis submitted to the Faculty of Graduate Studies and Research In partial fulfillment of the requirements of the degree of Doctor of Philosophy Department of Psychology ©Georgia Peggy McFall Spring 2014 Edmonton, Alberta Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only.
Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the authors prior written permission. Dedication Good work is done in the presence of passion and commitment. Great work is done in the presence of love and support. We did this together Richard James Katie Marie Patrick Joseph Sean Abstract Objective: This gene x environment (health) dissertation focused on concurrent and longitudinal change in performance on executive function (EF) and declarative memory (DM) latent variables by normal aging adults.
Specifically, we report three studies that tested the independent and interactive effects of (a) Insulin degrading enzyme (IDE) and type 2 diabetes (T2D) across 2 waves of EF data, (b) IDE and pulse pressure (PP) across 3 waves of EF data, and (c) Apolipoprotein E (ApoE) and PP across 3 waves of DM data for older adults from the Victoria Longitudinal Study.
Method: We assembled a sample of nondemented ...





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