High Avidity dsDNA Autoantibodies in Brazilian Women with Systemic Lupus Erythematosus: Correlation with Active Disease and Renal DysfunctionReport as inadecuate




High Avidity dsDNA Autoantibodies in Brazilian Women with Systemic Lupus Erythematosus: Correlation with Active Disease and Renal Dysfunction - Download this document for free, or read online. Document in PDF available to download.

Journal of Immunology Research - Volume 2015 2015, Article ID 814748, 5 pages -

Research Article

Programa de Pós-Graduação em Imunologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, 40140-100 Salvador, BA, Brazil

Escola Bahiana de Medicina e Saúde Pública, 40050-420 Salvador, BA, Brazil

Laboratório de Pesquisa em Imunologia, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão de Jeremoabo 147, 40170-115 Salvador, BA, Brazil

Received 21 November 2014; Accepted 16 March 2015

Academic Editor: Thomas Dörner

Copyright © 2015 Rodrigo C. Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated in Brazilian women with SLE the prevalence and levels of high avidity HA dsDNA antibodies and tested their correlation with lupus activity and biomarkers of renal disease. We also compared these correlations to those observed with total dsDNA antibodies and antibodies against nucleosome ANuA. Autoantibodies were detected by ELISA, while C3 and C4 levels were determined by nephelometry. Urine protein-creatinine ratio was determined, and lupus activity was measured by SLEDAI-2K. The prevalence of total and HA dsDNA antibodies was similar to but lower than that verified for ANuA. The levels of the three types of antibodies were correlated, but the correlation was more significant between HA dsDNA antibodies and ANuA. High avidity dsDNA antibodies correlated positively with ESR and SLEDAI and inversely with C3 and C4. Similar correlations were observed for ANuA levels, whereas total dsDNA antibodies only correlated with SLEDAI and C3. The levels of HA dsDNA antibodies were higher in patients with proteinuria, but their levels of total dsDNA antibodies and ANuA were unaltered. High avidity dsDNA antibodies can be found in high prevalence in Brazilian women with SLE and are important biomarkers of active disease and kidney dysfunction.





Author: Rodrigo C. Oliveira, Isabela S. Oliveira, Mittermayer B. Santiago, Maria L. B. Sousa Atta, and Ajax M. Atta

Source: https://www.hindawi.com/



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