Understanding the Added Value of G-Protein-Coupled Receptor HeteromersReport as inadecuate




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Scientifica - Volume 2014 2014, Article ID 362937, 7 pages -

Review ArticleDepartment Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Prevosti Building, Diagonal 645, 08028 Barcelona, Spain

Received 11 December 2013; Accepted 10 March 2014; Published 22 April 2014

Academic Editors: A. Contestabile, A. Fuso, and J. Stegmuller

Copyright © 2014 Nuria Franco and Rafael Franco. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

G-protein-coupled receptors GPCRs constitute the most populated family of proteins within the human genome. Since the early sixties work on GPCRs and on GPCR-mediated signaling has led to a number of awards, the most recent being the Nobel Prize in Chemistry for 2012. The future of GPCRs research is surely based on their capacity for heteromerization. Receptor heteromers offer a series of challenges that will help in providing success in academic-basic research and translation into more effective and safer drugs.





Author: Nuria Franco and Rafael Franco

Source: https://www.hindawi.com/



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