Ten-Year Cumulative Incidence of Diabetic Retinopathy. The Beijing Eye Study 2001-2011Report as inadecuate




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Objective

To assess the cumulative 10-year incidence of diabetic retinopathy DR and its associated factors in a population living in Greater Beijing.

Methods

The population-based longitudinal Beijing Eye Study, which included 4439 subjects age in 2001: 40+years in 2001, was repeated in 2011 with 2695 subjects participating 66.4% of the survivors. The study participants underwent a detailed ophthalmic examination. Fundus photographs were examined for the new development of DR.

Results

After excluding individuals with DR at baseline n = 87 or no sufficient fundus photographs in 2011 n = 6, the study included 2602 subjects with a mean age of 64.6±9.7 years median: 64.0 years; range: 50 to 93 years. In the 10-year period, 109 subjects 39 men developed new DR with an incidence of 4.2% 95% confidence interval CI: 3.45,5.03. In multiple logistic regression analysis, incident DR was significantly associated with higher HbA1c value P<0.001; Odds Ratio OR: 1.73; 95% Confidence Interval CI: 1.35,2.21, longer duration of diabetes mellitus P<0.001; OR: 1.16; 95% CI: 1.10,1.22, higher serum concentration of creatinine P = 0.02; OR: 1.01; 95% CI: 1.002,1.022, lower educational level P = 0.049; OR: 0.74; 95% CI: 0.55,0.99, higher estimated cerebrospinal fluid pressure P = 0.038; OR: 1.10; 95% CI: 1.01,1.22, and shorter axial length P<0.001; OR: 0.48; 95% CI: 0.33,0.71.

Conclusions

The cumulative 10-year incidence mean: 4.2% of DR in a North Chinese population was significantly associated with a higher HbA1c value, longer known duration of diabetes mellitus, higher estimated CSFP and shorter axial length P<0.001. Shorter axial length or hyperopia and, potentially, higher CSFP may be additional risk factors to be taken into account when counseling and treating patients with diabetes mellitus.



Author: Jie Xu, Liang Xu, Ya Xing Wang, Qi Sheng You, Jost B. Jonas, Wen Bin Wei

Source: http://plos.srce.hr/



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