Adding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple SclerosisReport as inadecuate




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Multiple Sclerosis InternationalVolume 2013 2013, Article ID 319201, 9 pages

Research Article

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, S848 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA

Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA

Division of Gastroenterology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA

Neuroimmunology-Multiple Sclerosis Division, Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA

Received 12 June 2013; Accepted 14 August 2013

Academic Editor: Mark S. Freedman

Copyright © 2013 David J. Levinthal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Multiple sclerosis MS patients often suffer from gastrointestinal GI symptoms. However, the full extent and prevalence of such symptoms are not clearly established. Thus, we sought to define the prevalence of GI symptoms and syndromes in those with MS. Methods. 218 MS patients completed self-reported demographic and clinical data questionnaires as well as several standardized surveys probing MS severity and GI health. Results. Nearly two thirds 65.6% of patients endorsed at least one persistent GI symptom. Constipation 36.6%, dysphagia 21.1%, and fecal incontinence 15.1% were common. Surprisingly, nearly 30% 28.4% of the patients reported dyspeptic symptoms. Using validated diagnostic algorithms, patients met criteria for functional dysphagia 14.7%, functional dyspepsia 16.5%, functional constipation 31.7%, and IBS 19.3%, among others. Functional dysphagia, functional dyspepsia, and IBS were significantly more common in those with self-identified mood disorders. Conclusions. Constipation, fecal incontinence, and dysphagia are indeed frequent symptoms seen in MS patients. We also noted a ~30% prevalence of dyspepsia in this population. The mechanisms driving this association are not clear and require further study. However, due to this high prevalence, dyspeptic symptoms should be incorporated into the routine assessment of MS patients and, if found, may warrant collaborative referral with a GI specialist.





Author: David J. Levinthal, Ambreen Rahman, Salman Nusrat, Margie O’Leary, Rock Heyman, and Klaus Bielefeldt

Source: https://www.hindawi.com/



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