Effect of Vitamin D Supplementation on Cardiometabolic Risks and Health-Related Quality of Life among Urban Premenopausal Women in a Tropical Country – A Randomized Controlled TrialReport as inadecuate




Effect of Vitamin D Supplementation on Cardiometabolic Risks and Health-Related Quality of Life among Urban Premenopausal Women in a Tropical Country – A Randomized Controlled Trial - Download this document for free, or read online. Document in PDF available to download.

Background

Many observational studies linked vitamin D to cardiometabolic risks besides its pivotal role in musculoskeletal diseases, but evidence from trials is lacking and inconsistent.

Aim

To determine whether Vitamin D supplementation in urban premenopausal women with vitamin D deficiency can improve cardiometabolic risks and health-related quality of life HRQOL.

Design

A double-blind randomized controlled trial was conducted in Kuala Lumpur, Malaysia. A total of 192 vitamin D deficient <50 nmol-l premenopausal women were randomized to receive either vitamin D 50,000 IU or placebo once a week for 2 months and then monthly for 10 months. Primary outcomes were serum 25OHD, serum lipid profiles, blood pressure and HOMA-IR measured at baseline, 6 months and 12 months. HRQOL was assessed with SF-36 at baseline and 12 months.

Results

Ninety three and ninety-nine women were randomised into intervention and placebo groups respectively. After 12 months, there were significant differences in the serum 25OHD concentration mean difference: 49.54; 95% CI: 43.94 to 55.14 nmol-l and PTH levels mean difference: −1.02; 95% CI: −1.67 to −0.38 pmol-l in the intervention group compared to placebo group. There was significant difference between treatment group in both serum 25OHD and PTH. There was no effect of supplementation on HOMA-IR, serum lipid profiles and blood pressure all p>0.05 between two groups. There was a small but significant improvement in HRQOL in the components of vitality mean difference: 5.041; 95% CI: 0.709 to 9.374 and mental component score mean difference: 2.951; 95% CI: 0.573 to 5.329 in the intervention group compared to placebo group.

Conclusion

Large and less frequent dosage vitamin D supplementation was safe and effective in the achievement of vitamin D sufficiency. However, there was no improvement in measured cardiometabolic risk factors in premenopausal women. Conversely vitamin D supplementation improves some components of HRQOL.

Trial Registration

Australian New Zealand Clinical Trial Registry ACTRN12612000452897



Author: Mazliza Ramly , Moy Foong Ming, Karuthan Chinna, Suhaili Suboh, Rokiah Pendek

Source: http://plos.srce.hr/



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