Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from ChinaReport as inadecuate




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BioMed Research International - Volume 2016 2016, Article ID 6491049, 6 pages -

Research ArticleDepartment of Abdominal Surgery, National Cancer Center-Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Received 6 July 2016; Revised 24 October 2016; Accepted 26 October 2016

Academic Editor: Sonshin Takao

Copyright © 2016 Qing-Long Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To evaluate the clinical risk factors influencing overall survival of patients with duodenal adenocarcinoma after potentially curative resection. Methods. A series of 201 patients with primary duodenal adenocarcinoma who underwent surgery from 1999 to 2014 at Chinese Medical Academic Cancer Hospital were studied by retrospective chart review and subsequent telephone follow-up. Results. Resectional surgery was performed in 138 of the 201 patients to attempt curative treatment, while 63 patients were treated with palliative surgery. Median survival of patients who underwent resectional operation was 57 months, whereas that of patients who had palliative surgery was shorter, 7 months . For patients who underwent radical resection, the overall 1-, 3-, and 5-year survival rates were 87.3, 59.1, and 44.1%, respectively. Multivariate Cox regression analysis revealed that lymph node metastasis HR 31.76, 2.14 to 470.8; and vascular invasion HR 3.75, 1.24 to 11.38; were independent prognostic factors negatively associated with survival in patients undergoing curative resection. There was no survival difference between the groups treated by the pancreaticoduodenectomy and limited resection for early-stage duodenal adenocarcinoma . Conclusions. Duodenal adenocarcinoma is a rare disease. Curative resection is the best treatment for appropriate patients. Lymph node metastases and vascular invasion are negative prognostic factors.





Author: Qing-Long Jiang, Xiang-Hui Huang, Ying-Tai Chen, Jian-Wei Zhang, and Cheng-Feng Wang

Source: https://www.hindawi.com/



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