Sensitivity of various body indices and visceral adiposity index in predicting metabolic syndrome among Chinese patients with adult growth hormone deficiencyReport as inadecuate

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Journal of Endocrinological Investigation

, Volume 40, Issue 6, pp 653–661

First Online: 23 February 2017Received: 27 August 2016Accepted: 18 January 2017DOI: 10.1007-s40618-017-0621-2

Cite this article as: Qing, L., Wei, R., Chan, L. et al. J Endocrinol Invest 2017 40: 653. doi:10.1007-s40618-017-0621-2


AimAdult growth hormone deficiency AGHD refers to decreased secretion of growth hormones in the adults, which is associated with increased clustering of conventional cardiovascular risk factors such as central obesity, insulin resistance and dyslipidemia. Metabolic syndrome MetS, a recognized risk factor of cardiovascluar diseases, shares some clinical features. Given that the prevalence of MetS is on the rise in patients with AGHD, and that cardiovascular disease CVD is an important cause of morbidity and mortality in that population, the alternative, simple, non-invasive methods of assessing MetS among this population are needed. This study aims to determine the sensitivity of five anthropometric indices Body mass index BMI, Waist circumference WC, Waist-to-hip ratio WHR, Waist-to-height ratio WHtR and Visceral adiposity index VAI in predicting metabolic syndrome in Chinese population-based patients with adult growth hormone deficiency.

Materials and methodsA total of 96 Chinese patients with adult growth hormone deficiency were included in this study. They were compared with equal number of apparently healthy persons with similar characteristics matched with age and gender to the previous group. Anthropometric measurements including weight, height, serum lipids indices, blood pressure BP, fasting plasma glucose FPG, WC were measured. BMI, WHR, WHtR, and VAI were calculated.

Results and discussionAGHD patients with MetS had higher WC 91.00 ± 8.28 vs 78.01 ± 7.12, BMI 24.95 ± 2.91 VS 23.30 ± 2.80, WHR 0.92 ± 0.06 VS 0.87 ± 0.07, WHtR 0.53 ± 0.06 VS 0.47 ± 0.05, VAI 5.59 4.02, 7.55 VS 1.69 0.87, 3.05 levels in comparison to those without MetS. Meantime WC, BMI, WHR, WHtR, VAI was positively correlated to MetS components. ROC curve for participants with AGHD showed that VAI had the highest SS of 92% BMI 0.812; WHR 0.706; WHtR 0.902; VAI 0.920, respectively for prediction of MetS in AGHD. The optimal cutoff values for different adiposity markers in predicting MetS were as follows: WC 79.65, BMI 23.46; WHR 0.89; WHtR 0.54; VAI 2.29.

ConclusionIn conclusion, our study showed all adiposity measures of interest present themselves as easy and practical tools for use in population studies and clinical practice for evaluating MetS in AGDH and VAI was identified as the best in Chinese AGHD patients among them.

KeywordsVisceral adiposity index Body adiposity index Metabolic syndrome Adult growth hormone deficiency 

Author: L. Qing - R. Wei - L. Chan - Z. Xiaoya - X. Xin


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