Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorumReport as inadecuate

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International Nano Letters

, Volume 7, Issue 2, pp 157–164

First Online: 07 April 2017Received: 21 June 2016Accepted: 28 December 2016DOI: 10.1007-s40089-016-0198-3

Cite this article as: Dorostkar, R., Ghalavand, M., Nazarizadeh, A. et al. Int Nano Lett 2017 7: 157. doi:10.1007-s40089-016-0198-3


In the present study, zinc oxide ZnO and iron oxide FeO nanoparticles were examined for their possible, in vitro anthelmintic effects against Toxocara vitulorum. The worms were incubated for 24 h with different concentrations 0.004, 0.008 and 0.012% w-v of the nanoparticles. The parasite mobility, mortality, superoxide dismutase SOD activity, malondialdehyde MDA and nitric oxide NO level were recorded at different time intervals. The results showed that both of the nanoparticles could significantly decrease worm’s mobility, increase mortality rate as well as elevate MDA and NO content as compared to control group in a time- and concentration-dependent manner. SOD activity was elevated with the low concentration of the nanoparticles but it was decreased in higher ones. It can be concluded that ZnO and FeO nanoparticles exert their anthelmintic effects via induction of oxidative-nitrosative stress.

KeywordsToxocara vitulorum Anthelmintic Zinc oxide FeOn oxide Nanoparticle 

Author: Ruhollah Dorostkar - Majdedin Ghalavand - Ali Nazarizadeh - Mahdi Tat - Mohammad Sadegh Hashemzadeh


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