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Radiation Oncology

, 12:93

Radiation Physics

Abstract

BackgroundLung cancer patients are often in poor physical condition, and a shorter treatment time would reduce their discomfort. Dynamic conformal arc therapy DCAT offers a shorter treatment time than conventional 3D conformal radiotherapy 3D CRT and is usually available even in departments without inverse planning possibilities. We examined its suitability as a treatment modality for lung cancer patients.

MethodsOn a cohort of 35 lung cancer patients, relevant dosimetric parameters were compared in respective DCAT and 3D CRT treatment plans. Radiochromic film dosimetry in an anthropomorphic phantom was used to compare both DCAT and 3D CRT dose distributions against their planned counterparts.

ResultsIn comparison with their 3D CRT counterparts, DCAT plans equal or exceed the agreement between the calculated dose and the dose measured using film dosimetry. In dosimetric comparison, DCAT performed significantly better than 3D CRT in dose conformity to PTV and the number of monitor units used per plan, and significantly worse in dose homogeneity, mean lung dose and lung volume exposed to 5 Gy or more V5Gy. No significant difference was found in the V20Gy value to lung, dose to 1 cm of spinal cord, and the mean dose to oesophagus. Improvements in V20Gy and V5Gy were found to be negatively correlated. DCAT plans differ from 3D CRT by exhibiting a moderate negative correlation between target volume sphericity and dose homogeneity.

ConclusionsWith respect to the agreement between the planned and the irradiated dose distribution, DCAT appears at least as reliable as 3D CRT. In specific conditions concerning the patient anatomy and treatment prescription, DCAT may yield more favourable dosimetric parameters. On average, however, conventional 3D CRT usually obtains better dosimetric parameters. We can thus only recommend DCAT as a complementary technique to the conventional 3D CRT.

KeywordsDynamic conformal arc therapy Film dosimetry Lung cancer Electronic supplementary materialThe online version of this article doi:10.1186-s13014-017-0823-y contains supplementary material, which is available to authorized users.





Author: Primož Peterlin - Karmen Stanič - Ignasi Méndez - Andrej Strojnik

Source: https://link.springer.com/







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