Association between TLR4 896A-G and 1196C-T Polymorphisms and Gastric Cancer Risk: An Updated Meta-AnalysisReport as inadecuate




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Background

Toll-like receptor 4 TLR4 is a receptor of lipopolysaccharide in the signaling transduction of gastric epithelial cell. It plays a pivotal role in activation of innate immunity and pathogen recognition and thus acts as a modulator in the development and progression of gastric cancer. Growing studies explored the association of polymorphisms in TLR4 with susceptibility to gastric cancer, but the results have remained controversial and conflicting. To investigate the effect of two selected TLR4 +896A-G and +1196C-T polymorphisms on gastric cancer, we performed a meta-analysis.

Methods

A comprehensive search was conducted to identify all eligible case-control publications investigating the association between TLR4 polymorphisms and gastric cancer risk. Odds ratios OR and corresponding 95% confidence intervals CI were used to assess such association.

Results

Up to March 26 2014, 10 published case-control studies from PubMed and EMBase were available, involving a total of 1888 gastric cancer patients and 3433 control subjects. In the overall meta-analyses, a significantly increased gastric cancer risk was detected in TLR4 +896A-G polymorphism heterozygous model, AG vs. AA: OR = 1.67, 95% CI, 1.39–2.01; additive model, G vs. A: OR = 1.64, 95% CI, 1.37–1.95 and TLR4 +1196C-T polymorphism heterozygous model, CT vs. CC: OR = 1.42, 95% CI, 1.11–1.81; additive model, T vs. C: OR = 1.36, 95% CI, 1.08–1.72, similar results were obtained in the subgroup analyses of Caucasian, whereas no associations were detected in any genetic models of non-Caucasian.

Conclusions

The overall results suggest that TLR4 polymorphisms +896A-G and +1196C-T may be associated with a significantly increased gastric cancer risk in Caucasian.



Author: Quan Zhou, Chenchen Wang, Xiaofeng Wang, Xiongyan Wu, Zhenggang Zhu, Bingya Liu , Liping Su

Source: http://plos.srce.hr/



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