Adiponectin Alleviates Genioglossal Mitochondrial Dysfunction in Rats Exposed to Intermittent HypoxiaReport as inadecuate




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Background

Genioglossal dysfunction is involved in the pathophysiology of obstructive sleep apnea hypoxia syndrome OSAHS characterized by nocturnal chronic intermittent hypoxia CIH. The pathophysiology of genioglossal dysfunction and possible targeted pharmacotherapy for alleviation of genioglossal injury in CIH require further investigation.

Methodology-Principal Findings

Rats in the control group were exposed to normal air, while rats in the CIH group and CIH+adiponectin AD group were exposed to the same CIH condition CIH 8 hr-day for 5 successive weeks. Furthermore, rats in CIH+AD group were administrated intravenous AD supplementation at the dosage of 10 µg, twice a week for 5 consecutive weeks. We found that CIH-induced genioglossus GG injury was correlated with mitochondrial dysfunction, reduction in the numbers of mitochondrias, impaired mitochondrial ultrastructure, and a reduction in type I fibers. Compared with the CIH group, impaired mitochondrial structure and function was significantly improved and a percentage of type I fiber was elevated in the CIH+AD group. Moreover, compared with the control group, the rats’ GG in the CIH group showed a significant decrease in phosphorylation of LKB1, AMPK, and PGC1-α, whereas there was significant rescue of such reduction in phosphorylation within the CIH+AD group.

Conclusions

CIH exposure reduces mitochondrial biogenesis and impairs mitochondrial function in GG, while AD supplementation increases mitochondrial contents and alleviates CIH-induced mitochondrial dysfunction possibly through the AMPK pathway.



Author: Hanpeng Huang , Xiufeng Jiang , Yanbin Dong, Xiaofeng Zhang, Ning Ding, Jiannan Liu, Sean Z. Hutchinson, Gan Lu , Xilong Zhang

Source: http://plos.srce.hr/



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