Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked HydrogelReport as inadecuate




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Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked ADA-GEL hydrogel was synthesized through covalent crosslinking of alginate di-aldehyde ADA with gelatin that supported cell attachment, spreading and proliferation. This study highlights the evaluation of the physico-chemical properties of synthesized ADA-GEL hydrogels of different compositions compared to alginate in the form of films. Moreover, in vitro cell-material interaction on ADA-GEL hydrogels of different compositions compared to alginate was investigated by using normal human dermal fibroblasts. Viability, attachment, spreading and proliferation of fibroblasts were significantly increased on ADA-GEL hydrogels compared to alginate. Moreover, in vitro cytocompatibility of ADA-GEL hydrogels was found to be increased with increasing gelatin content. These findings indicate that ADA-GEL hydrogel is a promising material for the biomedical applications in tissue-engineering and regeneration.



Author: Bapi Sarker , Raminder Singh , Raquel Silva, Judith A. Roether, Joachim Kaschta, Rainer Detsch, Dirk W. Schubert, Iwona Cicha, Al

Source: http://plos.srce.hr/



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