Investigation of 6-18F-Fluoromaltose as a Novel PET Tracer for Imaging Bacterial InfectionReport as inadecuate




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Despite advances in the field of nuclear medicine, the imaging of bacterial infections has remained a challenge. The existing reagents suffer from poor sensitivity and specificity. In this study we investigate the potential of a novel PET positron emission tomography tracer that overcomes these limitations.

Methods

6-18F-fluoromaltose was synthesized. Its behavior in vitro was evaluated in bacterial and mammalian cultures. Detailed pharmacokinetic and biodistribution profiles for the tracer were obtained from a murine model.

Results

6-18F-fluoromaltose is taken up by multiple strains of pathogenic bacteria. It is not taken up by mammalian cancer cell lines. 6-18F-fluoromaltose is retained in infected muscles in a murine model of bacterial myositis. It does not accumulate in inflamed tissue.

Conclusion

We have shown that 6-18F-fluoromaltose can be used to image bacterial infection in vivo with high specificity. We believe that this class of agents will have a significant impact on the clinical management of patients.



Author: Gayatri Gowrishankar, Mohammad Namavari, Erwan Benjamin Jouannot, Aileen Hoehne, Robert Reeves, Jonathan Hardy, Sanjiv Sam Gambhi

Source: http://plos.srce.hr/



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