Population Snapshot of Streptococcus pneumoniae Causing Invasive Disease in South Africa Prior to Introduction of Pneumococcal Conjugate VaccinesReport as inadecuate




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We determined the sequence types of isolates that caused invasive pneumococcal disease IPD prior to routine use of pneumococcal conjugate vaccines PCV in South Africa. PCV-13 serotypes and 6C isolates collected in 2007 1 461-2 437, 60% from patients of all ages as part of on-going, national, laboratory-based surveillance for IPD, were selected for genetic characterization. In addition, all 134 non-PCV isolates from children <2 years were selected for characterization. Sequence type diversity by serotype and age category children <5 years vs. individuals ≥5 years was assessed for PCV serotypes using Simpson’s index of diversity. Similar genotypes circulated among isolates from children and adults and the majority of serotypes were heterogeneous. While globally disseminated clones were common among some serotypes e.g., serotype 1 clonal complex CC 217, 98% of all serotype 1 and 14 CC230, 43%, some were represented mainly by clonal complexes rarely reported elsewhere e.g., serotype 3 CC458, 60% and 19A CC2062, 83%. In children <2 years, serotype 15B and 8 were the most common serotypes among non-PCV isolates 16% 22-134 and 15% 20-134 isolates, respectively. Sequence type 7052 and 53 were most common among serotypes 15B and 8 isolates and accounted for 58% 7-12 and 64% 9-14 of the isolates, respectively. Serotype 19F, 14, 19A and 15B had the highest proportions of penicillin non-susceptible isolates. Genotypes rarely reported in other parts of the world but common among some of our serotypes highlight the importance of our data as these genotypes may emerge post PCV introduction.



Author: Kedibone M. Ndlangisa , Mignon du Plessis, Nicole Wolter, Linda de Gouveia, Keith P. Klugman, Anne von Gottberg, for GERMS-SA

Source: http://plos.srce.hr/



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