Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis: A Systematic Review and Meta-AnalysisReport as inadecuate




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Background

Objective was to determine whether prophylactic low level laser therapy LLLT reduces the risk of severe mucositis as compared to placebo or no therapy.

Methods

MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials RCTs comparing prophylactic LLLT with placebo or no therapy in patients with cancer or undergoing hematopoietic stem cell transplantation HSCT. All analyses used random effects models.

Results

Eighteen RCTs 1144 patients were included. Prophylactic LLLT reduced the overall risk of severe mucositis risk ratio RR 0.37, 95% confidence interval CI 0.20 to 0.67; P = 0.001. LLLT also reduced the following outcomes when compared to placebo-no therapy: severe mucositis at the time of anticipated maximal mucositis RR 0.34, 95% CI 0.20 to 0.59, overall mean grade of mucositis standardized mean difference −1.49, 95% CI −2.02 to −0.95, duration of severe mucositis weighted mean difference −5.32, 95% CI −9.45 to −1.19 and incidence of severe pain RR 0.26, 95% CI 0.18 to 0.37.

Conclusion

Prophylactic LLLT reduced severe mucositis and pain in patients with cancer and HSCT recipients. Future research should identify the optimal characteristics of LLLT and determine feasibility in the clinical setting.



Author: Sapna Oberoi, Gabriele Zamperlini–Netto, Joseph Beyene, Nathaniel S. Treister, Lillian Sung

Source: http://plos.srce.hr/



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