Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in MiceReport as inadecuate




Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice - Download this document for free, or read online. Document in PDF available to download.

Taurine 2-aminoethanesulfonic acid is found in milimolar concentrations in mammalian tissues. One of its main functions is osmoregulation; however, it also exhibits cytoprotective activity by diminishing injury caused by stress and disease. Taurine depletion is associated with several defects, many of which are found in the aging animal, suggesting that taurine might exert anti-aging actions. Therefore, in the present study, we examined the hypothesis that taurine depletion accelerates aging by reducing longevity and accelerating aging-associated tissue damage. Tissue taurine depletion in taurine transporter knockout TauTKO mouse was found to shorten lifespan and accelerate skeletal muscle histological and functional defects, including an increase in central nuclei containing myotubes, a reduction in mitochondrial complex 1 activity and an induction in an aging biomarker, Cyclin-dependent kinase 4 inhibitor A p16INK4a. Tissue taurine depletion also enhances unfolded protein response UPR, which may be associated with an improvement in protein folding by taurine. Our data reveal that tissue taurine depletion affects longevity and cellular senescence; an effect possibly linked to a disturbance in protein folding.



Author: Takashi Ito , Natsumi Yoshikawa, Takaaki Inui, Natsuko Miyazaki, Stephen W. Schaffer, Junichi Azuma

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents