New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease NAFLDReport as inadecuate




New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease NAFLD - Download this document for free, or read online. Document in PDF available to download.

Protein and Cell

pp 1–14

First Online: 22 June 2017Received: 17 March 2017Accepted: 31 May 2017DOI: 10.1007-s13238-017-0436-0

Cite this article as: Zhang, X., Ji, X., Wang, Q. et al. Protein Cell 2017. doi:10.1007-s13238-017-0436-0 ABSTRACT

Non-alcoholic fatty liver disease NAFLD is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD. In this review, we emphasize on the current understanding of the inter-organ crosstalk between the liver and peripheral organs that contributing to the pathogenesis of NAFLD.

KEYWORDSnon-alcoholic fatty liver disease hepatic lipid metabolism hypothalamus gut-liver axis adipose tissue 



Author: Xu Zhang - Xuetao Ji - Qian Wang - John Zhong Li

Source: https://link.springer.com/







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