Risks of asphyxia-related neonatal complications in offspring of mothers with type 1 or type 2 diabetes: the impact of maternal overweight and obesityReport as inadecuate




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Diabetologia

, Volume 60, Issue 7, pp 1244–1251

First Online: 13 April 2017Received: 25 November 2016Accepted: 20 March 2017DOI: 10.1007-s00125-017-4279-2

Cite this article as: Cnattingius, S., Lindam, A. & Persson, M. Diabetologia 2017 60: 1244. doi:10.1007-s00125-017-4279-2

Abstract

Aims-hypothesisWe aimed to compare the risks of severe asphyxia-related neonatal complications in the offspring of mothers with type 1 or type 2 diabetes, and to assess the impact of maternal overweight-obesity on these risks.

MethodsThis was a population-based study of 1,343,751 live-born singleton infants in Sweden between 1997 and 2011, including 5941 and 711 infants of mothers with type 1 and type 2 diabetes, respectively. ORs with 95% CIs were calculated for low Apgar score 0–6 at 5 min after birth, hypoxic ischaemic encephalopathy and neonatal seizures.

ResultsThe rates of a low Apgar score were 0.9%, 2.6% and 2.1% in the offspring of mothers without diabetes or with type 1 or type 2 diabetes, respectively. After controlling for maternal confounders including BMI, the risk of a low Apgar score increased in the offspring of mothers with type 1 diabetes OR 2.67, 95% CI 2.23, 3.20 but not in the offspring of mothers with type 2 diabetes OR 1.25, 95% CI 0.66, 2.35. The ORs of hypoxic ischaemic encephalopathy or neonatal seizures were increased in the offspring of mothers with type 1 diabetes OR 3.41, 95% CI 2.58, 4.49 and type 2 diabetes OR 2.54, 95% CI 1.13, 5.69. Maternal overweight-obesity was a risk factor for asphyxia-related neonatal complications and low Apgar scores in the offspring of mothers with type 1 diabetes and mothers without diabetes.

Conclusions-interpretationThe risks of a low Apgar score and severe asphyxia-related neonatal complications are increased in the offspring of mothers with type 1 or type 2 diabetes. Maternal overweight-obesity is an important contributing factor.

KeywordsApgar score Asphyxia Asphyxia-related neonatal morbidity Body mass index BMI Diabetes type 1 Diabetes type 2 Obesity Overweight AbbreviationsHIEHypoxic ischaemic encephalopathy

MBRMedical Birth Register





Author: Sven Cnattingius - Anna Lindam - Martina Persson

Source: https://link.springer.com/







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