DNA Interaction and DNA Cleavage Studies of a New PlatinumII Complex Containing Aliphatic and Aromatic Dinitrogen LigandsReport as inadecuate




DNA Interaction and DNA Cleavage Studies of a New PlatinumII Complex Containing Aliphatic and Aromatic Dinitrogen Ligands - Download this document for free, or read online. Document in PDF available to download.

Bioinorganic Chemistry and ApplicationsVolume 2011 2011, Article ID 525794, 10 pages

Research ArticleDepartment of Chemistry, Faculty of Science, Razi University, Kermanshah 74155, Iran

Received 20 July 2011; Revised 16 September 2011; Accepted 20 September 2011

Academic Editor: Cláudio M. Gomes

Copyright © 2011 Nahid Shahabadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new PtII complex, PtDIPLLNO32 in which DIP is 4,7-diphenyl-1,10-phenanthroline and LL is the aliphatic dinitrogen ligand, N,N-dimethyl-trimethylenediamine, was synthesized and characterized using different physico-chemical methods. The interaction of this complex with calf thymus DNA CT-DNA was investigated by absorption, emission, circular dichroism CD, and viscosity measurements. The complex binds to CT-DNA in an intercalative mode. The calculated binding constant, Kb, was  M

. The enthalpy and entropy changes of the reaction between the complex and CT-DNA showed that the van der Waals interactions and hydrogen bonds are the main forces in the interaction with CT-DNA. In addition, CD study showed that phenanthroline ligand insert between the base pair stack of double helical structure of DNA. It is remarkable that this complex has the ability to cleave the supercoiled plasmid.





Author: Nahid Shahabadi, Soheila Kashanian, Maryam Mahdavi, and Noorkaram Sourinejad

Source: https://www.hindawi.com/



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