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CholesterolVolume 2012 2012, Article ID 490381, 4 pages

Research Article

Cardiology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Pediatrics Department, Faculty of Medicine and Child Growth & Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Received 4 April 2012; Accepted 10 May 2012

Academic Editor: Khosrow Adeli

Copyright © 2012 Mohammad Hashemi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The association of diabetes and atherosclerosis with disorders of lipids and lipoproteins, notably high apolipoprotein B apoB and low apolipoprotein A1apoA1 is well established. Because of the beginning of the atherosclerosis- process from early life, in this study, the plasma levels of apoA1 and apoB were compared in diabetic children with type I diabetes mellitusDM, healthy children with diabetic parents HDPs,and healthy children with nondiabetic parents HNDPs. Methods. This case-control study was conducted among 90 children aged 9–18 years. Serum levels of apoA and apoB were compared among 30 diabetic children DM, 30 healthy children with diabetic parents HDPs, and 30 healthy children with nondiabetic parents HNDP. Results. The mean serum apoA1 was higher in DM  mg-dL followed by HNDPs  mg-dL and HDPs  mg-dl, but the difference was not statistically significant. The mean apoB value in HNDPs was significantly lower than DM and HDPs  mg-dL versus and  mg-dL, , respectively. The mean apoB levels in DM  mg-dl and HDP  mg-dL were not statistically significantly different . Conclusions. Diabetic children and healthy children with diabetic parents are at higher risk of dyslipidemia and atherosclerosis. Thus for primordial and primary prevention of atherosclerosis, we suggest screening these children for low plasma apoA1 and high plasma apoB levels.





Author: Mohammad Hashemi, Mohammad Saadat, Mohaddeseh Behjati, and Roya Kelishadi

Source: https://www.hindawi.com/



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