Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of BacteriaReport as inadecuate




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Disease Markers - Volume 2015 2015, Article ID 653537, 7 pages -

Research Article

Department d’Estomatología, Facultat de Medicina y Odontología, Universitat de València, C- Gascó Oliag 1, 46010 Valencia, Spain

Fundación Investigación Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, C- Menéndez y Pelayo 4, 46010 Valencia, Spain

Received 4 June 2015; Accepted 15 July 2015

Academic Editor: Anna Zalewska

Copyright © 2015 Jose Manuel Almerich-Silla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. Methods. A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal healthy as control. Oxidative stress biomarkers 8-OHdG and MDA, total antioxidant capacity TAOC, and the activity of two antioxidant enzymes GPx and SOD were determined in saliva. Subgingival plaque samples were obtained from the deepest periodontal pocket and PCR was used to determine the presence of the 6 fimA genotypes of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Treponema denticola. Results. Periodontal disease was found to be associated with increased oxidative stress parameter levels. These levels rose according to the number and type of different periodontal bacteria found in the periodontal pockets. The presence of different types of periodontal bacteria is predictive independent variables in linear regresion models of oxidative stress parameters as dependent variable, above all 8-OHdG. Conclusions. Oxidative stress parameter levels are correlated with the presence of different types of bacteria. Determination of these levels and periodontal bacteria could be a potent tool for controlling periodontal disease development.





Author: Jose Manuel Almerich-Silla, Jose María Montiel-Company, Sara Pastor, Felipe Serrano, Miriam Puig-Silla, and Francisco Dasí

Source: https://www.hindawi.com/



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