Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga SpeciesReport as inadecuate




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The Scientific World JournalVolume 2013 2013, Article ID 312741, 8 pages

Research Article

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Al-Moalim Bin Laden Chair for Scientific Miracles of Prophetic Medicine, Scientific Chairs Unit, Taibah University, P.O. Box 30001, Madinah al Munawarah 41311, Saudi Arabia

Received 23 August 2013; Accepted 17 September 2013

Academic Editors: C. Timchalk and S. Wu

Copyright © 2013 Nor Aishah Mazlan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The methanol extracts of three Macaranga species M. denticulata, M. pruinosa, and M. gigantea were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide NO production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. denticulata showed the highest total phenolic content 2682 mg gallic acid equivalent GAE-100 g and free radical scavenging activity IC50 = 0.063 mg-mL. All of the samples inhibited linoleic acid peroxidation by greater than 80%, with the leaves of M. gigantea exhibiting the highest inhibition of 92.21%. Most of the samples exhibited significant antioxidant potential. The bark of M. denticulata and the leaves of both M. pruinosa and M. gigantea exhibited greater than 50% tyrosinase inhibition, with the bark of M. denticulata having the highest percentage of inhibition 68.7%. The bark and leaves of M. denticulata exhibited greater than 50% inhibition 73.82% and 54.50%, resp. of the acetylcholinesterase enzyme AChE, while none of the samples showed any significant inhibition of butyrylcholinesterase BChE. Only the bark of M. denticulata and M. gigantea displayed greater than 50% inhibition of nitric oxide production in cells 81.79% and 56.51%, resp

These bioactivities indicate that some Macaranga spp. have therapeutic potential in medicinal research.





Author: Nor Aishah Mazlan, Ahmed Mediani, Faridah Abas, Syahida Ahmad, Khozirah Shaari, Shamsul Khamis, and N. H. Lajis

Source: https://www.hindawi.com/



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