Correlations of MTHFR 677C>T Polymorphism with Cardiovascular Disease in Patients with End-Stage Renal Disease: A Meta-AnalysisReport as inadecuate




Correlations of MTHFR 677C>T Polymorphism with Cardiovascular Disease in Patients with End-Stage Renal Disease: A Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Objective

This meta-analysis was conducted to evaluate the correlations of a common polymorphism 677C>T in the methylenetetrahydrofolate reductase MTHFR gene with risk of cardiovascular disease CVD in patients with end-stage renal disease ESRD.

Method

The following electronic databases were searched without language restrictions: Web of Science 1945∼2013, the Cochrane Library Database Issue 12, 2013, MEDLINE 1966∼2013, EMBASE 1980∼2013, CINAHL 1982∼2013 and the Chinese Biomedical Database CBM 1982∼2013. Meta-analysis was performed using STATA statistical software. Odds ratios ORs with their 95% confidence intervals 95%CIs were calculated.

Results

Eight cohort studies met all inclusion criteria and were included in this meta-analysis. A total of 2,292 ESRD patients with CVD were involved in this meta-analysis. Our meta-analysis results revealed that the MTHFR 677C>T polymorphism might increase the risk of CVD in ESRD patients TT vs. CC: OR = 2.75, 95%CI = 1.35∼5.59, P = 0.005; CT+TT vs. CC: OR = 1.39, 95%CI = 1.09∼1.78, P = 0.008; TT vs. CC+CT: OR = 2.52, 95%CI = 1.25∼5.09, P = 0.010; respectively. Further subgroup analysis by ethnicity suggested that the MTHFR 677C>T polymorphism was associated with an elevated risk for CVD in ESRD patients among Asians TT vs. CC: OR = 3.38, 95%CI = 1.11∼10.28, P = 0.032; CT+TT vs. CC: OR = 1.44, 95%CI = 1.05∼1.97, P = 0.022; TT vs. CC+CT: OR = 3.15, 95%CI = 1.02∼9.72, P = 0.046; respectively, but not among Africans or Caucasians all P>0.05.

Conclusion

Our findings indicate that the MTHFR 677C>T polymorphism may be associated with an elevated risk for CVD in ESRD patients, especially among Asians.



Author: Xian-Hui Gao , Guo-Yi Zhang, Ying Wang, Hui-Ying Zhang

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents