Contextual and Auditory Fear Conditioning Continue to Emerge during the Periweaning Period in RatsReport as inadecuate




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Anxiety disorders often emerge during childhood. Rodent models using classical fear conditioning have shown that different types of fear depend upon different neural structures and may emerge at different stages of development. For example, some work has suggested that contextual fear conditioning generally emerges later in development postnatal day 23–24 than explicitly cued fear conditioning postnatal day 15–17 in rats. This has been attributed to an inability of younger subjects to form a representation of the context due to an immature hippocampus. However, evidence that contextual fear can be observed in postnatal day 17 subjects and that cued fear conditioning continues to emerge past this age raises questions about the nature of this deficit. The current studies examine this question using both the context pre-exposure facilitation effect for immediate single-shock contextual fear conditioning and traditional cued fear conditioning using Sprague-Dawley rats. The data suggest that both cued and contextual fear conditioning are continuing to develop between PD 17 and 24, consistent with development occurring the in essential fear conditioning circuit.



Author: Michael A. Burman , Kristen J. Erickson, Alex L. Deal, Rose E. Jacobson

Source: http://plos.srce.hr/



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