Association of Gln27Glu and Arg16Gly Polymorphisms in Beta2-Adrenergic Receptor Gene with Obesity Susceptibility: A Meta-AnalysisReport as inadecuate




Association of Gln27Glu and Arg16Gly Polymorphisms in Beta2-Adrenergic Receptor Gene with Obesity Susceptibility: A Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Background

The beta2-adrenergic receptor ADRB2 gene polymorphism has been implicated in susceptibility to obesity, but study results are still controversial.

Objective

The present meta-analysis is performed to determine whether there are any associations between the Gln27Glu rs1042714 or the Arg16Gly rs1042713 polymorphisms in ADRB2 and obesity susceptibility.

Methods

The PubMed 1950–2014, Embase 1974–2014, and China National Knowledge Infrastructure CNKI, 1994–2014 databases were searched using the search terms -Beta2-adrenergic receptor- -β2-adrenergic receptor- or -ADRB2- -polymorphism,- and -obesity-. Fixed- or random-effects pooled measures were determined on the bias of heterogeneity tests across studies. Publication bias was examined by Egger-s test and the modified Begg-s test.

Results

Eighteen published articles were selected for meta-analysis. Overall analyses showed that rs1042714 Gln27Glu was associated with significantly increased obesity risk in the heterozygote model Gln-Glu vs. Gln-Gln: OR: 1.16, 95% CI: 1.04–1.30, I2 = 49%, P = 0.009 and the dominant model Gln-Glu + Glu-Glu vs. Gln-Gln: OR: 1.2, 95% CI: 1.00–1.44, I2 = 55%, P = 0.04, whereas no significant association was found in the other models for rs1042714. Also, no significant association was found between the rs1042713 Arg16Gly gene polymorphism and the risk of obesity in all genetic models. In addition, neither rs1042713 Arg16Gly nor rs1042714 Gln27Glu showed any significant association with obesity susceptibility when the population were stratified based on gender.

Conclusion

Our meta-analysis revealed that the rs1042714 Gln27Glu polymorphism is associated with obesity susceptibility. However, our results do not support an association between rs1042713 Arg16Gly polymorphisms and obesity in the populations investigated. This conclusion warrants confirmation by more case-control and cohort studies.



Author: Hongxiu Zhang , Jie Wu, Lipeng Yu

Source: http://plos.srce.hr/



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