Increased Plasma YKL-40-Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep ApneaReport as inadecuate




Increased Plasma YKL-40-Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea - Download this document for free, or read online. Document in PDF available to download.

Purpose

Obstructive sleep apnea OSA is a common disorder affecting 15–24% of the adults and is associated with increased risk of hypertension and atherosclerosis. The exact mechanisms underlying hypertension in OSA are not entirely clear. YKL-40-Chitinase-3-like protein-1 is a circulating moiety with roles in injury, repair and angiogenesis that is dysregulated in atherosclerosis and a number of other diseases. We sought to determine the role of YKL-40 in endothelial dysfunction and hypertension in OSA.

Methods

We studies 23 normotensive OSA N-OSA and 14 hypertensive OSA H-OSA without diabetes and apparent cardiovascular disease. Endothelial-dependent nitric oxide-mediated vasodilatory capacity was assessed by flow-mediated vasodilation FMD. YKL-40, vascular endothelial growth factor VEGF and the soluble form of VEGF receptor-1or sFlt-1 were measured in plasma using ELISA methodology.

Results

N-OSA subjects aged 49.1±2.3 years and H-OSA aged 51.3±1.9 years with BMI 36.1±1.6 and 37.6±1.9 kg-m2, respectively. The apnea-hypopnea index AHI was 41±5 events-hr in N-OSA and 46±6 in H-OSA with comparable degree of oxygen desaturations during sleep. FMD was markedly impaired in H-OSA 8.3%±0.8 compared to N-OSA 13.2%±0.6, P<0.0001. Plasma YKL-40 was significantly elevated in H-OSA 55.2±7.9 ng-ml vs. 35.6±4.2 ng-ml in N-OSA, P = 0.02 and had an inverse relationship with FMD r = −0.52, P = 0.013. There was a significant positive correlation between sFlt-1-VEGF, a measure of decreased VEGF availability, and YKL-40 r = 0.42, P = 0.04.

Conclusion

The levels of plasma YKL-40 were elevated in H-OSA group and inversely correlated with the endothelial-dependent vasodilatory capacity whereas there was a positive correlation between sFlt-1-VEGF and YKL-40. These findings suggest that YKL-40 is dysregulated, in part, due to perturbation of VEGF signaling, and may contribute to endothelial dysfunction and hypertension in OSA.



Author: Behrouz Jafari, Jack A. Elias, Vahid Mohsenin

Source: http://plos.srce.hr/



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