Genetic Polymorphism of Glutathione S Transferases M1 and T1 in Indian Patients with Hepatocellular CarcinomaReport as inadecuate




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Disease Markers - Volume 28 2010, Issue 6, Pages 369-376



Department of Medicine, Maulana Azad Medical College, University of Delhi, India

Department of Biosciences, Jamia Millia Islamia, New Delhi, India

Institute of Cytology and Preventive Oncology, ICMR, Noida, India

Department of Gastroenterology, Madurai Medical College, Madurai, Tamil Nadu, India

Department of Microbiology, Guru Nanak Dev University, Amritsar, India

Received 16 July 2010; Accepted 16 July 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: Our aim was to evaluate whether the association of GSTM1-T1 gene polymorphisms modifies the risk of Hepatocellular carcinoma HCC and what is its correlation with other predisposing risk factors like alcohol intake, cigarette smoking and hepatitis B and C infections.

Study design-setting: It was a case-control study, included 254 HCC cases compared with 525 hospital-based age and sex matched cases of chronic liver disease without HCC as controls from Indian population. The GSTM1 and GSTT1 genotypes were detected using conventional multiplex PCR method.

Results: In this case-control study, we observed a positive correlation between age, HBV and HCV infection, smoking habit of > 20 packs-year, alcohol consumption of > 100 g-day and risk of liver cancer. We found significantly increased risk associated with GSTM1 null genotype OR = 3.49; 95% CI = 2.52–4.84 as well as GSTT1 null genotype OR = 3.12; 95% CI = 2.19–4.45, respectively. However, an increased risk of HCC was observed among heavy drinkers with GSTM1 OR = 2.01; 95% CI = 1.11–3.66. Further, cigarette smoking showed a non-significant association with GSTT1 OR = 1.49; CI = 0.69–3.25.

Conclusion: Our results suggest that the variants in low penetrance gene such as GSTM1 and GSTT1 are associated with an increased liver cancer risk. Further, an influence of GSTM1-T1 null genotypes may contribute in the etiology of HCC in patients with higher cigarette and alcohol consumption.





Author: Mohammad Asim, Luqman A. Khan, S. A. Husain, Sajid Husain, Manash P. Sarma, Istaq Ahmad, J. K. Sharma, Anita Sharma, Shashi Sharm

Source: https://www.hindawi.com/



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