Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and OsteoporosisReport as inadecuate

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BioMed Research International - Volume 2014 2014, Article ID 290531, 13 pages -

Review ArticleDepartment of Orthopaedics, Drum Tower Hospital, Medical School of Nanjing University, Zhongshan Road No. 321, Nanjing 210008, China

Received 14 June 2014; Revised 10 September 2014; Accepted 10 September 2014; Published 14 December 2014

Academic Editor: Mohammad I. Kamboh

Copyright © 2014 Guang-Yue Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The low-density lipoprotein receptor-related protein 5 gene LRP5 was identified to be linked to the variation in bone mineral density and types of bone diseases. The present study was aimed at examining the association of LRP5 rs3736228 C>T gene with bone fracture and osteoporosis by meta-analysis. A systematic electronic search of literature was conducted to identify all published studies in English or Chinese on the association of the LRP5 gene with bone fracture and osteoporosis risks. All analyses were calculated using the Version 12.0 STATA software. Odds ratios ORs and their corresponding 95% confidence interval 95% CI were calculated. An updated meta-analysis was currently performed, including seven independent case-control studies. Results identified that carriers of rs3736228 C>T variant in the LRP5 gene were associated with an increased risk of developing osteoporosis and fractures under 4 genetic models but not under the dominant model OR = 1.19, 95% CI = 0.97~1.46, and . Ethnicity-subgroup analysis implied that LRP5 rs3736228 C>T mutation was more likely to develop osteoporosis and fractures among Asians and Caucasians in majority of subgroups. These results suggest that there is a modest effect of the LRP5 rs3736228 C>T on the increased susceptibility of bone fracture and osteoporosis.

Author: Guang-Yue Xu, Yong Qiu, and Hai-Jun Mao



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