A Ten-MicroRNA Signature Identified from a Genome-Wide MicroRNA Expression Profiling in Human Epithelial Ovarian CancerReport as inadecuate




A Ten-MicroRNA Signature Identified from a Genome-Wide MicroRNA Expression Profiling in Human Epithelial Ovarian Cancer - Download this document for free, or read online. Document in PDF available to download.

Epithelial ovarian cancer EOC is the most common gynecologic malignancy. To identify the micro-ribonucleic acids miRNAs expression profile in EOC tissues that may serve as a novel diagnostic biomarker for EOC detection, the expression of 1722 miRNAs from 15 normal ovarian tissue samples and 48 ovarian cancer samples was profiled by using a quantitative real-time polymerase chain reaction qRT-PCR assay. A ten-microRNA signature hsa-miR-1271-5p, hsa-miR-574-3p, hsa-miR-182-5p, hsa-miR-183-5p, hsa-miR-96-5p, hsa-miR-15b-5p, hsa-miR-182-3p, hsa-miR-141-5p, hsa-miR-130b-5p, and hsa-miR-135b-3p was identified to be able to distinguish human ovarian cancer tissues from normal tissues with 97% sensitivity and 92% specificity. Two miRNA clusters of miR183-96-183 miR-96-5p, and miR-182, miR183 and miR200 miR-141-5p, miR200a, b, c and miR429 are significantly up-regulated in ovarian cancer tissue samples compared to those of normal tissue samples, suggesting theses miRNAs may be involved in ovarian cancer development.



Author: Lin Wang, Miao-Jun Zhu, Ai-Min Ren, Hong-Fei Wu, Wu-Mei Han, Ruo-Ying Tan , Rui-Qin Tu

Source: http://plos.srce.hr/



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