Association between Phosphorylated AMP-Activated Protein Kinase and Acetyl-CoA Carboxylase Expression and Outcome in Patients with Squamous Cell Carcinoma of the Head and NeckReport as inadecuate




Association between Phosphorylated AMP-Activated Protein Kinase and Acetyl-CoA Carboxylase Expression and Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck - Download this document for free, or read online. Document in PDF available to download.

Background

Epidemiological studies have indicated that impaired glucose metabolism may increase the risk of squamous cell carcinoma of the head and neck SCCHN. AMP-activated protein kinase AMPK regulates glucose and lipid metabolism via the phosphorylation and subsequent inactivation of its downstream target acetyl-CoA carboxylase ACC.Thus, we analyzed the expression of pAMPK and its downstream target phosphorylated acetyl-CoA carboxylase pACC, as well as their impact on the survival of patients with resected SCCHN.

Methods

One hundred eighteen patients with surgically resected SCCHN were enrolled. Immunohistochemical IHC staining for pAMPK and pACC was performed using tissue microarrays of operative specimens of SCCHN. The expression was divided into two or three groups according to the IHC score pAMPK: negative 0, positive 1–3; pACC: negative 0, low expression 1, 2, and high expression 3. Statistical analysis was performed to determine the association of pAMPK expression with clinicopathological features and pACC and pErk expression.

Results

The positive rates of pAMPK and pACC expression were 64.4% 76-118 and 68.6% 81-118, respectively. pAMPK was significantly higher in patients aged younger than 60 years P = 0.024; χ2test and those with early-stage T1-T2; P = 0.02; χ2 test and oral cavity P = 0.026; Fisher’s exact test tumors. In multivariate analysis, pAMPK expression was not significantly correlated with overall survival OS adjusted hazard ratio HR: 0.66; 95% confidence interval CI: 0.35–1.23, whereas high pACC expression was independently associated with worse OS in node-positive patients adjusted HR: 17.58; 95% CI: 3.50–88.18.

Conclusions

Strong expression of pACC was found to be an independent prognostic marker for patients with node-positive SCCHN. Our results suggest that pACC may play a role in tumor progression of SCCHN and may help to identify patient subgroups at high risk for poor disease outcome.



Author: Ying-Wen Su, Yun-Ho Lin, Man-Hui Pai, An-Chi Lo, Yu-Chieh Lee, I-Chih Fang, Johnson Lin, Ruey-Kuen Hsieh, Yi-Fang Chang, Chi-Long

Source: http://plos.srce.hr/



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