Fetal Exposure to Perfluorinated Compounds and Attention Deficit Hyperactivity Disorder in ChildhoodReport as inadecuate




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Background

The association between exposure to perfluorinated compounds PFCs and attention deficit hyperactivity disorder ADHD diagnosis has been sparsely investigated in humans and the findings are inconsistent.

Objectives

A matched case-control study was conducted to investigate the association between fetal exposure to PFCs and ADHD diagnosis in childhood.

Methods

The study base comprised children born in Malmö, Sweden, between 1978 and 2000 that were followed up until 2005. Children with ADHD n = 206 were identified at the Department of Child and Adolescent Psychiatry. Controls n = 206 were selected from the study base and were matched for year of birth and maternal country of birth. PFC concentrations were measured in umbilical cord serum samples. The differences of the PFC concentrations between cases and controls were investigated using Wilcoxon-s paired test. Possible threshold effects above the upper quartile for perfluorooctane sulfonate PFOS and perfluorooctanoic acid PFOA and above limit of detection LOD for perfluorononanoic acid PFNA were evaluated by conditional logistic regression.

Results

The median umbilical cord serum concentrations of PFOS were 6.92 ng-ml in the cases and 6.77 ng-ml in the controls. The corresponding concentrations of PFOA were 1.80 and 1.83 ng-ml. No associations between PFCs and ADHD were observed. Odds ratios adjusted for smoking status, parity, and gestational age were 0.81 95% confidence interval CI 0.50 to 1.32 for PFOS, 1.07 95% CI 0.67 to 1.7 for PFOA, and 1.1 95% CI 0.75 to 1.7 for PFNA.

Conclusions

The current study revealed no support for an association between fetal exposure to PFOS, PFOA, or PFNA and ADHD.



Author: Amanda Ode , Karin Källén, Peik Gustafsson, Lars Rylander, Bo A. G. Jönsson, Per Olofsson, Sten A. Ivarsson, Christian H. Lind

Source: http://plos.srce.hr/



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