Positive Lymph Node Metastasis Has a Marked Impact on the Long-Term Survival of Patients with Hepatocellular Carcinoma with Extrahepatic MetastasisReport as inadecuate




Positive Lymph Node Metastasis Has a Marked Impact on the Long-Term Survival of Patients with Hepatocellular Carcinoma with Extrahepatic Metastasis - Download this document for free, or read online. Document in PDF available to download.

Background

The prognosis of hepatocellular carcinoma HCC patients with extrahepatic metastasis is extremely poor. However, what is the main risk factor for survival remains unclear for these patients. We aimed to find out the relative frequency, incidence and locations of extrahepatic metastases and the risk factors of long-term survival of the patients.

Methods

132 HCC patients with extrahepatic metastasis diagnosed by 18F-FDG PET-CT and conventional workup were enrolled into this study. The incidence and locations of extrahepatic metastases were summarized, and the related risk factors of overall survival were analyzed.

Results

The most frequent extrahepatic metastatic sites were lymph nodes in 72 54.5%, bone in 33 25.0% and lung in 28 21.2% patients. On univariate analysis, prothrombin time, Child-Pugh grade, portal-hepatic vein invasion and lymph node metastasis were independent risk factors of overall survival. On multivariate analysis, lymph node metastasis was the only independent risk factor of overall survival. The cumulative survival rates at 1- and 3-years after diagnosis of extrahepatic metastasis of HCC were 34.4% and 9.3%, respectively. The median survival time was 7 months range 1 ∼38 months. The median survival time for patients with or without lymph node metastasis were 5 months range 1∼38 months and 12 months range 1∼30 months, respectively P = 0.036.

Conclusions

This study showed lymph nodes to be the most frequent site of extrahepatic metastases for primary HCC. Lymph node metastasis was the main risk factor of overall survival in patients with HCC with extrahepatic metastasis.



Author: Feng Xia , Lin Wu , Wan-Yee Lau, Guo Li, Hongbo Huan, Cheng Qian, Kuansheng Ma, Ping Bie

Source: http://plos.srce.hr/



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