Protective Effects of Rosa damascena and Its Active Constituent on Aβ25–35-Induced Neuritic AtrophyReport as inadecuate




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RETRACTED The article has been retracted upon the authors- request. After the article had been accepted, the authors successfully carried out total synthesis of the compound 1 mentioned in this article. However, the data of the synthesized compound did not match with that of compound 1. Therefore, the structure of the proposed compound 1 should be wrongand the correct structure remains unknown.

Evidence-Based Complementary and Alternative MedicineVolume 2011 2011, Article ID 131042, 8 pages

Original Article

Division of Natural Products Chemistry, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

Antianti Co. Ltd, Japan, 5-8 Hatago-Machi, Toyama, Japan

Received 12 May 2009; Accepted 30 August 2009

Copyright © 2011 Suresh Awale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dementia is a clinical syndrome characterized by multiple cognitive deficits and causes progressive neurodegeneration leading eventually to death. The incidence of dementia is increasing worldwide with the increase in ageing population. However, no effective treatment is available yet. It has been hypothesized that drugs activating neurite outgrowth might induce neuronal reconstruction and help in the recovery of brain function. Working on this hypothesis, we recently observed that the chloroform extract of the Rosa damascena significantly induced the neurite outgrowth activity and inhibited the Aβ25–35-induced atrophy and cell death. Further workup led the isolation of a very long polyunsaturated fatty acid having molecular formula C37H64O2 as an active constituent. The structure of this compound was established by extensive analysis of fragmentations observed in EI-MS mode. The isolated compound protected Aβ25–35-induced atrophy and displayed strong neurite outgrowth activity. The length of dendrite in the cells treated with this compound were comparable to those of nerve growth factor NGF treated cells.





Author: Suresh Awale, Chihiro Tohda, Yasuhiro Tezuka, Makoto Miyazaki, and Shigetoshi Kadota

Source: https://www.hindawi.com/



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