Prognostic Value of Tumor-Infiltrating FoxP3 T Cells in Gastrointestinal Cancers: A Meta AnalysisReport as inadecuate




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Purpose

Tumor-infiltrating FoxP3+ T cells have been reported in various human tumors, which impaired cell-mediated immunity and promoted disease progression. However, its prognostic value for survival in patients with different gastrointestinal cancers hepatocellular carcinoma HCC, colorectal cancer CRC, gastric cancer GC remains controversial.

Methods

Relevant literature was searched using PubMed, Embase, Cochrane, Ovid Medline and Chinese wanfang databases. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. The odds ratio OR and 95% confidence intervals CI were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials.

Results

For HCC and GC, the overall survival at 1, 3 and 5-year of high FoxP3+ T cells infiltration patients were lower than low FoxP3+ T cells infiltration patients P<0.05. The recurrences at 1, 3 and 5-year of high FoxP3+ T cells infiltration patients were higher than low FoxP3+ T cells infiltration patients P<0.001. But for CRC, the overall survival at 1, 3 and 5-year of high FoxP3+ T cells infiltration patients were higher than low FoxP3+ T cells infiltration patients P<0.001. There were no differences in 1, 3 and 5-year recurrences between high and low FoxP3+ T cells infiltration patients P>0.05.

Conclusions

Our findings suggested that tumor-infiltrating FoxP3+ T cells were a factor for a poor prognosis for HCC and GC, but a good prognosis for CRC.



Author: Yong Huang , Huaiwei Liao , Yong Zhang, Rongfa Yuan, Fengmei Wang , Yingtang Gao, Peng Wang, Zhi Du

Source: http://plos.srce.hr/



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