Duffy Antigen Receptor for Chemokine DARC Polymorphisms and Its Involvement in Acquisition of Inhibitory Anti-Duffy Binding Protein II DBPII ImmunityReport as inadecuate




Duffy Antigen Receptor for Chemokine DARC Polymorphisms and Its Involvement in Acquisition of Inhibitory Anti-Duffy Binding Protein II DBPII Immunity - Download this document for free, or read online. Document in PDF available to download.

The Plasmodium vivax Duffy binding protein PvDBP and its erythrocytic receptor, the Duffy antigen receptor for chemokines DARC, are involved in the major P. vivax erythrocyte invasion pathway. An open cohort study to analyze DARC genotypes and their relationship to PvDBP immune responses was carried out in 620 volunteers in an agricultural settlement of the Brazilian Amazon. Three cross-sectional surveys were conducted at 6-month intervals, comprising 395, 410, and 407 subjects, respectively. The incidence rates of P. vivax infection was 2.32 malaria episodes per 100 person-months under survey 95% confidence interval CI of 1.92-2.80-100 person-month and, of P. falciparum, 0.04 per 100 person-months 95% CI of 0.007–0.14-100 person-month. The distribution of DARC genotypes was consistent with the heterogeneous ethnic origins of the Amazon population, with a predominance of non-silent DARC alleles: FY*A > FY*B. The 12-month follow-up study demonstrated no association between DARC genotypes and total IgG antibodies as measured by ELISA targeting PvDBP region II, DBPII or regions II–IV, DBPII-IV. The naturally acquired DBPII specific binding inhibitory antibodies BIAbs tended to be more frequent in heterozygous individuals carrying a DARC-silent allele FY*BES. These results provide evidence that DARC polymorphisms may influence the naturally acquired inhibitory anti-Duffy binding protein II immunity.



Author: Flávia A. Souza-Silva , Letícia M. Torres , Jessica R. Santos-Alves, Michaelis Loren Tang, Bruno A. M. Sanchez, Tais N. Sousa,

Source: http://plos.srce.hr/



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