Kaposis Sarcoma-Associated Herpesvirus KSHV vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 ActivationReport as inadecuate




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Kaposi-s sarcoma-associated herpesvirus KSHV is etiologically associated with Kaposi-s sarcoma KS, the most common AIDS-related malignancy. KSHV vIL-6 promotes KS development, but the exact mechanisms remain unclear. Here, we reported that KSHV vIL-6 enhanced the expression of DNA methyltransferase 1 DNMT1 in endothelial cells,increased the global genomic DNA methylation, and promoted cell proliferation and migration. And this effect could be blocked by the DNA methyltransferase inhibitor, 5-azadeoxycytidine. We also showed that vIL-6 induced up-regulation of DNMT1 was dependent on STAT3 activation. Therefore, the present study suggests that vIL-6 plays a role in KS tumorigenesis partly by activating DNMT1 and inducing aberrant DNA methylation, and it might be a potential target for KS therapy.



Author: Jing Wu, Yuqiao Xu, Dongping Mo, Peijun Huang, Ruihong Sun, Lei Huang, Shiyang Pan , Jian Xu

Source: http://plos.srce.hr/



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