Spontaneous BOLD Signal Fluctuations in Young Healthy Subjects and Elderly Patients with Chronic Kidney DiseaseReport as inadecuate




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Spontaneous fluctuations in blood oxygenation level-dependent BOLD images are the basis of resting-state fMRI and frequently used for functional connectivity studies. However, there may be intrinsic information in the amplitudes of these fluctuations. We investigated the possibility of using the amplitude of spontaneous BOLD signal fluctuations as a biomarker for cerebral vasomotor reactivity.We compared the coefficient of variation CV of the time series defined as the temporal standard deviation of the time series divided by the mean signal intensity in two populations: 1 Ten young healthy adults and 2 Ten hypertensive elderly subjects with chronic kidney disease CKD.We found a statistically significant increase P<0.01 in the CV values for the CKD patients compared with the young healthy adults in both gray matter GM and white matter WM. The difference was independent of the exact segmentation method, became more significant after correcting for physiological signals using RETROICOR, and mainly arose from very low frequency components of the BOLD signal fluctuation f<0.025 Hz. Furthermore, there was a strong relationship between WM and GM signal fluctuation CV-s R2 = 0.87 in individuals, with a ratio of about 1∶3.These results suggest that amplitude of the spontaneous BOLD signal fluctuations may be used to assess the cerebrovascular reactivity mechanisms and provide valuable information about variations with age and different disease states.



Author: Hesamoddin Jahanian , Wendy W. Ni, Thomas Christen, Michael E. Moseley, Manjula Kurella Tamura, Greg Zaharchuk

Source: http://plos.srce.hr/



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