Predictors of Full Enteral Feeding Achievement in Very Low Birth Weight InfantsReport as inadecuate




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Background

To elucidate the role of prenatal, neonatal and early postnatal variables in influencing the achievement of full enteral feeding FEF in very low birth weight VLBW infants and to determine whether neonatal intensive care units NICUs differ in this outcome.

Methods

Population-based retrospective cohort study using data on 1,864 VLBW infants drawn from the -Emilia-Romagna Perinatal Network- Registry from 2004 to 2009. The outcome of interest was time to FEF achievement. Eleven prenatal, neonatal and early postnatal variables and the study NICUs were selected as potential predictors of time to FEF. Parametric survival analysis was used to model time to FEF as a function of the predictors. Marginal effects were used to obtain adjusted estimates of median time to FEF for specific subgroups of infants.

Results

Lower gestational age, exclusive formula feeding, higher CRIB II score, maternal hypertension, cesarean delivery, SGA and PDA predicted delayed FEF. NICUs proved to be heterogeneous in terms of FEF achievement. Newborns with PDA had a 4.2 days longer predicted median time to FEF compared to those without PDA; newborns exclusively formula-fed had a 1.4 days longer time to FEF compared to those fed human milk.

Conclusions

The results of our study suggest that time to FEF is influenced by clinical variables and NICU-specific practices. Knowledge of the variables associated with delayed-earlier FEF achievement could help in improving specific aspects of routine clinical management of VLBW infants and to reduce practice variability.



Author: Luigi Corvaglia, Maria Pia Fantini, Arianna Aceti , Dino Gibertoni, Paola Rucci, Dante Baronciani, Giacomo Faldella, on behalf of

Source: http://plos.srce.hr/



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