Combined Oral Contraception and Obesity Are Strong Predictors of Low-Grade Inflammation in Healthy Individuals: Results from the Danish Blood Donor Study DBDSReport as inadecuate




Combined Oral Contraception and Obesity Are Strong Predictors of Low-Grade Inflammation in Healthy Individuals: Results from the Danish Blood Donor Study DBDS - Download this document for free, or read online. Document in PDF available to download.

Background

C-reactive protein CRP is a well-established marker of inflammation. The level of CRP is affected by several lifestyle factors. A slightly increased CRP level, also known as low-grade inflammation LGI, is associated with increased risk of several diseases, especially cardiovascular disease. The aim of this study was to identify predictors of increased CRP levels in healthy individuals. We therefore assessed CRP in a large cohort of blood donors.

Methods

We measured plasma CRP levels in 15,684 participants from the Danish Blood Donor Study. CRP was measured by a commercial assay. Furthermore, all participants completed a standard questionnaire on smoking status, alcohol consumption, physical activity, diet, and various body measurements. Female participants also reported the use of contraception, childbirth, and menopausal status. The relationship between LGI defined here as a plasma CRP level between 3 mg-L and 10 mg-L and predictors was explored by multivariable logistic regression analysis. Results were presented as odds ratios OR with 95% confidence intervals CI.

Results

We found LGI in a total of 1,561 10.0% participants. LGI was more frequent in women using combined oral contraception OC 29.9% than in men 6.1% and women not using OC 7.9%. Among premenopausal women, OC was the strongest predictor of LGI odds ratio = 8.98, p<0.001. Additionally, body mass index BMI and waist circumference were positively associated with LGI.

Conclusion

High BMI and abdominal obesity strongly predicted LGI among healthy individuals. However, the most striking finding was the high prevalence of LGI among premenopausal women who used combined oral contraception. Although the significance of CRP as a marker of inflammation is well known, the role of CRP in pathogenesis is still uncertain. The impact of oral contraception on CRP levels should nevertheless be considered when CRP is used in risk assessment.



Author: Cecilie J. Sørensen , Ole B. Pedersen, Mikkel S. Petersen, Erik Sørensen, Sebastian Kotzé, Lise W. Thørner, Henrik Hjalgrim,

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents