Worldwide Susceptibility Rates of Neisseria gonorrhoeae Isolates to Cefixime and Cefpodoxime: A Systematic Review and Meta-AnalysisReport as inadecuate




Worldwide Susceptibility Rates of Neisseria gonorrhoeae Isolates to Cefixime and Cefpodoxime: A Systematic Review and Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Background

Neisseria gonorrhoeae NG infection is a serious public health problem. The third-generation extended-spectrum cephalosporins ESCs have been used as the first-line treatment for NG infection for almost three decades. However, in recent years, treatment failures with the oral third-generation ESCs have been reported worldwide. This study aimed to estimate worldwide susceptibility rates of NG to cefixime and cefpodoxime by analyzing data from all relevant published studies.

Methodology-principal findings

Two researchers independently searched five databases to identify studies on susceptibilities of NG to cefixime and cefpodoxime published between January 1, 1984 and October 15, 2012. A fixed-effect model was used to perform group analysis, and a χ2 test was employed to make subgroup comparison. Publication bias was assessed with the Begg rank correlation test. The pooled susceptibility rate of NG isolates to cefixime was 99.8% 95% CI: 99.7%–99.8%. The cefixime susceptibility rate of NG isolates from men was significantly lower than that from patients without information of gender or from men and women; the susceptibility rate of NG isolates from Asia was significantly lower than that from other continents; and the susceptibility rate of NG isolates collected before or during 2003 was significantly higher than that after 2003. The pooled susceptibility rate of NG isolates to cefpodoxime was 92.8% 95% CI: 89.0%–95.3%, which was lower than that to cefixime 92.8% vs. 99.8%, χ2 = 951.809, P<0.01.

Conclusions

The susceptibility rate of NG isolates to cefixime varied with the gender of patients and geographical location from which NG isolates were collected, and declined with time. The reported lower susceptibility rate of NG isolates to cefixime and associated treatment failures, as well as the emergence of NG strains with cephalosporin resistance call for the more effective control of NG infection and the development of new antibiotics.



Author: Rui-xing Yu, Yueping Yin , Guan-qun Wang, Shao-chun Chen, Bing-jie Zheng, Xiu-qin Dai, Yan Han, Qi Li, Guo-yi Zhang, Xiangsheng C

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents