Uridine Prevents Fenofibrate-Induced Fatty LiverReport as inadecuate




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Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are examined. At a daily dosage of 400 mg-kg, fenofibrate treatment causes reduction of liver NAD+-NADH ratio, induces hyper-acetylation of peroxisomal bifunctional enzyme ECHD and acyl-CoA oxidase 1 ACOX1, and induces excessive accumulation of long chain fatty acids LCFA and very long chain fatty acids VLCFA. Uridine co-administration at a daily dosage of 400 mg-kg raises NAD+-NADH ratio, inhibits fenofibrate-induced hyper-acetylation of ECHD, ACOX1, and reduces accumulation of LCFA and VLCFA. Our data indicates a therapeutic potential for uridine co-administration to prevent fenofibrate-induced fatty liver.



Author: Thuc T. Le , Yasuyo Urasaki, Giuseppe Pizzorno

Source: http://plos.srce.hr/



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